Burkitt Lymphoma Research - 778 Words

Running Head: Burkitt Lymphoma Research Proposal in Kenya. Name of the Author University Affiliation Course Date of Submission Burkitt Lymphoma Research Proposal in Kenya. Burkitt Lymphoma (BL) is among the most aggressive cancerous tumors that attack humans. It is named after David Burkitt who first discovered and described this kind of tumor in children in Africa. It is more common in men than in women. The spread of this endemic is however rampant in both children and young adults. BL attacks people who have poor immunity. The research will revolve around Burkitt lymphoma (BL) and the Ubiquitin influences in inactivation the inactivation of the INK4/ARF locus in Burkitt lymphoma cell lines(Roberti, Rizzolio,†¦show more content†¦These are some of the problems and challenges expected whose answers lie with the success of the research and government guidelines and policy to license the production of the drugs. Internationally, among the medical researchers who take the line of Burkitt lymphoma are less than 300 annually. Highlighting and pinpointing the need of fresh and new graduates in particular, to dedicate themselves and venture into Bur kitt lymphoma research will definitely be a plus on the global scale of advance medical care and treatment for patients detected to contain this condition (Cozzi et al., 2011). References Cozzi, M., Giorgi, F., Marcelli, E., Pentimalli, F., Forte, I. M., Schenone, S, Giordano A. (2012). Antitumor activity of new pyrazolo [3, 4-d] pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition, 11, 1029-1039. Leukemia Lymphoma Society (LLS). (2009). Non-Hodgkin Lymphoma Magrath, I. (2012). Hindawi Publishing Corporation: Advances in Hematology. Towards Curative Therapy in Burkitt Lymphoma:TheRoleofEarlyAfricanStudiesinDemonstrating the Valueof CombinationTherapy and CNS Prophylaxis, 2012, 1-8. doi:10.1155/2012/130680. Roberti, A., Rizzolio, F., Lucchetti,C., Leval, L., Giordano, A. (2011). Ubiquitin-mediated protein degradation and methylation-induced gene silencing cooperate in the inactivation of the INK4/ARF locus in Burkitt lymphoma cell lines,Show MoreRelatedBurkitts Lymphoma Disease Essay3211 Words   |  13 Pages Burkitt’s lymphoma is a very aggressive form of B-cell non-Hodgkin lymphoma. The disease is related with Epstein-Barr virus and was one of the first tumours shown to have a chromosomal translocation. The Burkitt’s lymphoma disease is the most common childhood cancer where malaria is predominantly an epidemic. About10% of all malignant diseases in children under 15 years of age. Disease is very common in those whose immune system is not functionally efficient. With the help of intensive chemotherapyRead MoreEpstein Barr Virus ( Ebv )1416 Words   |  6 PagesINTRODUCTION Epstein-Barr virus was first discovered in 1964 by Sir Michael Anthony Epstein and Ms. Yvonne Barr. They located it in a Burkitt lymphoma cell line. It was the first virus to be associated with cancer. Infection of Epstein-Barr (EBV) is extremely widespread. The National Institutes of Health estimates that roughly 95% of people carry the virus. The virus was later found to cause infectious mononucleosis. Mononucleosis has since been nicknamed the â€Å"kissing disease†. TransmissionRead MoreBiography of Harald Zur Hausen1196 Words   |  5 PagesDNA of Epstem-Barr Virus in Burkitt s lymphoma cells that do not produce the complete infectious virus. He showed that Epstein-Barr virus DNA was present in Burkitt tumor tissue and in the tissue of another tumor, nasopharyngeal carcinoma, in multiple genome equivalents per cell. In 1977 he moved to a similar position to the University of Freiburg. From 1983 until 2003 he was appointed as Scientific Director of the Deutsches Krebsforschungszentrum (German Cancer Research Center) in Heidelberg. HeRead MoreCauses And Effects Of Cancer1048 Words   |  5 Pagesvirus is Epstein-Barr virus(EBV). Professor Epstein and his research colleague, Yvonne Barr, have used the first electron microscope in the world to discover the first human cancer virus from a sample of Burkitt Lymphoma - EBV. This tremendous discovery has changed the way of thinking about the causes of cancer; it marked the birth of new investigation that has grown to become one of the most important aspects of modern cancer research. (Crawford 4). EBV is a type of herpes virus that causes increasedRead MoreA Short Note On Non Hodgkin s Lymphoma1916 Words   |  8 PagesNon-Hodgkin’s lymphoma is one of the most common types of cancers in the United States that affect mostly older adults. The Ame rican Cancer Society estimates that 72,580 people in the Unites States will be diagnosed with the disease just in the year 2016 alone. Of that number, there are about 20,150 people expected to die from the disease. There is also a 2% chance of people in the United States developing the disease (American cancer society, n.d.). There have been many researches done about theRead MoreThe Merkel Cell ( Mcc )1459 Words   |  6 Pagesnaturally exposed to MCPyV, very few have MCC; therefore, other factors such as an immunosuppressed state likely contribute to viral integration, mutagenesis, and carcinogenesis [30]. Other tumors that have viral origins include Kaposi sarcoma and Burkitt lymphoma; these also have a higher incidence in immunodeficient patients. (MA, 2014)Another cause is DNA Damage and mutations during cell division. This is an issue because MCC also spread aggressively through the blood vessels, to lymph nodes, and otherRead MoreBiological Evolution Of Cancer And Its Effec ts On The World2073 Words   |  9 Pageseven longer than that of the human being, because before the appearance of human, there have been other animals and plants living in this planet, and the malignant tumor may just appear on any kinds of creatures. But the real beginning of cancer research only start from modern times. In 1775, Pott reported that the workers who clean the chimney are more easily to get carcinoma of scrotum. This drew the attention of people to the cancer and the factor of environment. In the end of 18th centuryRead MoreStructure And Function Of Proteins2165 Words   |  9 Pagesto the active site of the enzyme. Stated by Blaber (2001), the ‘lock and key’ model has been proposed by Fischer for this process, however, IB Guides (2012) state that the ‘induced fit’ model is more precise than the ‘lock and key’ model. Further research conducted by Koshland revealed that upon contact with a specific substrate, the shape of the active site of an enzyme changes slightly, causing the substrate to bind more tightly to the enzyme. Both models can be illustrated as shown in figure 1